Comparative activity of cecropin a and polymyxin b against frog bacterial pathogens

Authors

  • Ermin Schadich
  • Anthony Leonard James Cole
  • Drusilla Mason

Keywords:

frogs, antimicrobial, cecropin, bacteris, polymyxin, resistance

Abstract

The antimicrobial activity of two antimicrobial peptides, cecropin A and polymyxin B against different bacterial pathogens associated with bacterial dermatosepticemia, a fatal bacterial infectious disease of frogs was investigated. The peptides were tested in serial of concentrations (100-0.19 µg/ml) for growth inhibition of seven pathogens: Aeromonas hydrophila, Chryseobacterium meningosepticum, Citrobacter freundii, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis and Serratia liquefaciens. Their antimicrobial activity was compared with that of two antimicrobial peptides from frog skin, magainin 2 and aurein 2.1. Both cecropin A and polymyxin B, completely inhibited the growth of three pathogens: C. freundii, K. pneumoniae and P. aeruginosa at a concentration some sixteen times less than two skin peptides. Furthermore, cecropin A inhibited the growth of three pathogens resistant to the two skin peptides, A. hydrophila, C. meningosepticum and P. mirabilis. Polymyxin B also inhibited the growth of three pathogens resistant to the skin peptides, A. hydrophila, C. meningosepticum and S. liquefaciens. Cecropin A and polymyxin B have marked antibacterial activity against different frog bacterial pathogens indicating potential for therapeutic measures.

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Published

31-12-2020

How to Cite

Schadich, E. ., Cole, A. L. J. ., & Mason, D. . (2020). Comparative activity of cecropin a and polymyxin b against frog bacterial pathogens. VETERINARIA, 59(1-4), 67–73. Retrieved from https://veterinaria.unsa.ba/journal/index.php/vfs/article/view/164

Issue

Section

Research Article (peer review)