Histopathological pulp response of teeth capped with calcium aluminate cement and biodentine: Experimental study on rodents

Abstract

This study aimed to evaluate the pulpal response after pulp capping using experimental nanostructured calcium aluminate cement (ALBO-CA) and tricalcium silicate cement Biodentine (Septodont, Saint Maur des Fosses, France). Class I cavities were prepared on 72 teeth (36 first upper molars and 36-second upper molars) in 18 Wistar strain rats. The dental pulp was capped in 36 teeth with experimental ALBO-CA (group A) and 36 teeth with Biodentine (group B). All cavities were restored with glass ionomer. After 28 days animals were sacrificed and the following were analyzed: the inflammatory response of the pulp, the presence of bacteria, and the formation of a dentinal bridge. After 28 days, bacteria were not present. Mann-Whitney U test did not show a statistically significant difference in the inflammatory response of the pulp between the groups (U = 640.00; Z = 0.105; p = 0.916). The chi-square test did not
show a statistically significant difference in the formation of the dentinal bridge between the examined groups (Chi-square = 1,443; p = 0,230). ALBO-CA and Biodentine had similar effects on inflammation, pulp response, and formation of dental bridges in rats.