Toxicity testing of newly synthesized xanthene-3-ones after parenteral applications: an experimental study in rats (Rattus norvegicus)

Authors

  • Alisa Smajović
  • Muhamed Katica
  • Davorka Zavšnik
  • Elma Veljović
  • Alma Šeho-Alić
  • Jovana Šupić
  • Denis Čamo
  • Mirza Čelebičić
  • Selma Škrbo

Keywords:

Xanthenes, acute toxicity, in vivo study, rodents

Abstract

Xanthenes are organic compounds that can be of natural, semi-synthetic and synthetic origin. Many studies indicate that xanthene and its derivatives have antibacterial, antifungal, anthelmintic, antiprotozoal, anticancer and antidiabetic properties. In this study, the toxic effects of two newly synthesized xanthene compounds, 2,6,7-trihydroxy-9-(2-hydroxy-5-bromophenyl)- 3H-xanthene-3-one (COMPOUND 1) and 2,6,7-trihydroxy-9-(3-bromophenyl)-3H-xanthene-3-one (COMPOUND 2), were investigated in rats, Wistar strain. The compounds were administered by intramuscular and subcutaneous injections of 1 mL(0,156 mg/mL) once-daily for seven and 14 days, respectively. Histopathological analysis of selected parenchymatous organs revealed no changes indicating toxic effects, therefore, further studies on the subacute and chronic toxicity as well as potential pharmacological effects are required.

Downloads

Published

10-12-2020

How to Cite

Smajović, A. ., Katica, M., Zavšnik, D., Veljović, E., Šeho-Alić, A., Šupić, J., … Škrbo, S. (2020). Toxicity testing of newly synthesized xanthene-3-ones after parenteral applications: an experimental study in rats (Rattus norvegicus). VETERINARIA, 69(3), 205–212. Retrieved from https://veterinaria.unsa.ba/journal/index.php/vfs/article/view/250

Issue

Section

Research Article (peer review)

Most read articles by the same author(s)

1 2 3 > >>